In vivo GABA measurement using a PRESS-localized double quantum filter in patients with malformations of cortical development and epilepsy
نویسندگان
چکیده
Mary MCLEAN1, Robert SIMISTER2, Friedrich WOERMANN3, Lawrence WALD4, Stephen WILLIAMS5, John DUNCAN6 1National Society for Epilepsy, MRI Unit, Gerrards Cross, BUCKS UK; 2National Society for Epilepsy, MRI Unit, Gerrard's Cross, BUCKS UK; 3The National Society for Epilepsy, MRI Unit, Gerrards Cross, Bucks UK; 4Harvard University, MGH-NMR Center, Building 149, 13th Street, Charlestown, MA ; 5University of Manchester, Imaging Science & Biomedical Engr, Manchester, England, UK; 6University College London, Queen Square, London, United Kingdom;
منابع مشابه
Differential downregulation of GABAA receptor subunits in widespread brain regions in the freeze-lesion model of focal cortical malformations.
Focal cortical malformations comprise a heterogeneous group of disturbances of brain development, commonly associated with drug-resistant epilepsy and/or neuropsychological deficits. Electrophysiological studies on rodent models of cortical malformations demonstrated intrinsic hyperexcitability in the lesion and the structurally intact surround, indicating widespread imbalances of excitation an...
متن کاملIn vivo GABA detection with improved selectivity and sensitivity by localized double quantum filter technique at 4.1T.
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter for the normal function of mammal and human brain. It is difficult to detect GABA signal with the conventional single quantum technique due to its relatively low concentration and overlapping with other signals from creatine (Cr), glutathione (GSH), as well as macromolecules. Using a high-selective read pulse, DANTE, and at...
متن کاملA randomized clinical trial of repetitive transcranial magnetic stimulation in patients with refractory epilepsy.
OBJECTIVE To study the antiepileptic effects of rTMS in patients with refractory epilepsy and malformations of cortical development in a randomized, double-blind, sham-controlled trial. METHODS Twenty-one patients with malformations of cortical development and refractory epilepsy underwent five consecutive sessions of low-frequency rTMS, either sham or active (1Hz, 1,200 pulses), focally targ...
متن کاملA comparative study about toxicity of CdSe quantum dots on reproductive system development of mice and controlling this toxicity by ZnS coverage
Objective(s): Medicinal benefits of quantum dots have been proved in recent years but there is little known about their toxicity especially in vivo toxicity. In order to use quantum dots in medical applications, studies ontheir in vivo toxicity is important. Materials and Methods:CdSe:ZnS quantum dots were injected in 10, 20, and 40 mg/kg doses to male mice10 days later, mice were sacrificed ...
متن کاملLayer I ectopias and increased excitability in murine neocortex.
Cortical dysplasias are associated with both epilepsy and cognitive impairments in humans. Similarly, several animal models of cortical dysplasia show that dysplasia causes increased seizure susceptibility and behavioral deficits in vivo and increased levels of excitability in vitro. As most current animal models involve either global disruptions in cortical architecture or the induction of les...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2001